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Homeodomain Interacting Protein Kinase 2 (HIPK2)

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Homeodomain Interacting Protein Kinase 2 (HIPK2)
CCC F477
HGNC 14402
MGI 1314872
PubMed 17666529
RGD 1309349
UniProt Q9H2X6
Wiki HIPK2
HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.Hipk2 mRNA expression is detectable in day-15 mouse embryos and is strong in day-17 mouse embryos. The predicted 1,198-amino acid HIPK2 protein is 96% identical to the mouse protein and has a CD95-binding site between residues 754 and 899. Northern and dot blot analyses revealed weak but ubiquitous expression of an 11.0-kb transcript that was strongest in neuronal tissue. A 7.8-kb transcript was also detected in uterus, and a strong 1.4-kb transcript was found in pancreas. Confocal microscopy demonstrated a nuclear dot localization even with a C-terminal deletion or a kinase-defective mutant. HIPK2 expressed in cells did not directly associate with CD95 or TNFR1, but did associate with TRADD

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF477Hu01 Recombinant Homeodomain Interacting Protein Kinase 2 (HIPK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF477Hu01 Polyclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) WB; IHC; ICC; IP.
MAF477Hu21 Monoclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) WB; IHC; ICC; IP.
Assay Kits SEF477Hu ELISA Kit for Homeodomain Interacting Protein Kinase 2 (HIPK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeodomain Interacting Protein Kinase 2 (HIPK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF477Mu ELISA Kit for Homeodomain Interacting Protein Kinase 2 (HIPK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeodomain Interacting Protein Kinase 2 (HIPK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeodomain Interacting Protein Kinase 2 (HIPK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeodomain Interacting Protein Kinase 2 (HIPK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeodomain Interacting Protein Kinase 2 (HIPK2) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of cDNAs for the protein kinase HIPK2."Biochim. Biophys. Acta 1518:168-172(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells."Biochem. Biophys. Res. Commun. 277:513-517(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues."Biochem. Biophys. Res. Commun. 290:942-947(2002) [PubMed] [Europe PMC] [Abstract]
  5. "HIPK2 associates with RanBPM."Biochem. Biophys. Res. Commun. 297:148-153(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo."J. Biol. Chem. 277:32020-32028(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2."Nat. Cell Biol. 4:1-10(2002) [PubMed] [Europe PMC] [Abstract]
  8. "PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains."Cancer Res. 63:4310-4314(2003) [PubMed] [Europe PMC] [Abstract]
  9. "HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells."Cancer Res. 63:8271-8277(2003) [PubMed] [Europe PMC] [Abstract]
  10. "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity."J. Biol. Chem. 278:37722-37729(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation."J. Biol. Chem. 278:38998-39005(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression."Oncogene 22:8731-8737(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1."FEBS Lett. 579:6272-6278(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2."EMBO J. 25:1883-1894(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2."Mol. Cell 24:77-89(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity."J. Proteome Res. 6:4711-4719(2007) [PubMed] [Europe PMC] [Abstract]
  17. "PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis."Blood 112:3777-3787(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1."J. Biol. Chem. 283:4682-4689(2008) [PubMed] [Europe PMC] [Abstract]
  19. "PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation."Mol. Cell. Biol. 28:7126-7138(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR."Nat. Cell Biol. 10:812-824(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth."Biochim. Biophys. Acta 1793:368-377(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  23. "PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage."Oncogene 28:698-708(2009) [PubMed] [Europe PMC] [Abstract]
  24. "The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4."Oncogene 28:2535-2544(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha."PLoS ONE 4:E6819-E6819(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization."Biochem. Biophys. Res. Commun. 399:155-161(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation."Biochem. Biophys. Res. Commun. 394:966-971(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress."J. Cell Sci. 123:3863-3871(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271."Mol. Biol. Cell 21:2966-2974(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Control of nuclear HIPK2 localization and function by a SUMO interaction motif."Biochim. Biophys. Acta 1813:283-297(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53."Exp. Cell Res. 317:1060-1070(2011) [PubMed] [Europe PMC] [Abstract]
  32. "How cells switch HIPK2 on and off."Cell Death Differ. 16:187-194(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2."FEBS J. 276:6074-6083(2009) [PubMed] [Europe PMC] [Abstract]
  34. "HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1? inhibition."Cell Cycle 9:1270-1275(2010) [PubMed] [Europe PMC] [Abstract]
  35. "Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells."Oncogene 29:4378-4387(2010) [PubMed] [Europe PMC] [Abstract]
  36. "DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation."J. Biol. Chem. 287:30789-30799(2012) [PubMed] [Europe PMC] [Abstract]
  37. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  38. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]