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Centaurin Gamma 1 (CENTg1)

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AGAP2; GGAP2; PIKE; Arf-GAP With GTPase,ANK Repeat And PH Domain-Containing 2; GTP-binding and GTPase-activating protein 2; Phosphatidylinositol 3-kinase enhancer

Centaurin Gamma 1 (CENTg1)
CCC F464
HGNC 16921
MGI 3580016
PubMed 20080666
RGD 628844
UniProt Q99490
Wiki CENTG1
CENTg1 contains 836 amino acids. Northern blot analysis detected highest expression in brain, intermediate expression in skeletal muscle, spleen, thymus, and peripheral blood leukocytes, and weak expression in lung, liver, and small intestine. No expression was detected in kidney, pancreas, prostate, testis, ovary, and colon.
The 753-amino acid nuclear GTPase shares sequence homology with the GTP-binding domains of centaurin gamma-A, RAB7, and RRAS. Pike has 3 proline-rich domains (PRDs) in the N terminus, and in the C terminus, a Ras-like domain and a pleckstrin homology (PH) domain. Amino acid residues 387 to 752 of PIKE are virtually identical to residues 56 to 420 of the human cDNA KIAA0167.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Gamma 1 (CENTg1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Gamma 1 (CENTg1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Gamma 1 (CENTg1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Gamma 1 (CENTg1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Gamma 1 (CENTg1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Gamma 1 (CENTg1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Gamma 1 (CENTg1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Gamma 1 (CENTg1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Gamma 1 (CENTg1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Gamma 1 (CENTg1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Gamma 1 (CENTg1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Gamma 1 (CENTg1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Gamma 1 (CENTg1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Gamma 1 (CENTg1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Gamma 1 (CENTg1) ELISA Kit Customized Service Offer
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  3. "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis."Nat. Neurosci. 6:1153-1161(2003) [PubMed] [Europe PMC] [Abstract]
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  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion."J. Biol. Chem. 279:16441-16451(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt."Proc. Natl. Acad. Sci. U.S.A. 101:6993-6998(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3."J. Cell Sci. 118:3555-3566(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas."Neuropathol. Appl. Neurobiol. 31:486-490(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival."Cell Death Differ. 14:368-377(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The centaurin gamma-1 GTPase-like domain functions as an NTPase."Biochem. J. 401:679-688(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase."J. Mol. Biol. 378:425-435(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings."Proc. Natl. Acad. Sci. U.S.A. 102:16853-16858(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]