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F-Box Protein 7 (FBXO7)

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FBX; FBX07; FBX7

F-Box Protein 7 (FBXO7)
CCC F427
HGNC 13586
MGI 1917004
PubMed 21652635
RGD 1305648
UniProt Q9Y3I1
Wiki FBXO7
F-box only protein 7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 7 (FBXO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 7 (FBXO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 7 (FBXO7) Polyclonal Antibody Customized Service Offer
Assay Kits SEF427Hu ELISA Kit for F-Box Protein 7 (FBXO7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 7 (FBXO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 7 (FBXO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 7 (FBXO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 7 (FBXO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 7 (FBXO7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 7 (FBXO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 7 (FBXO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 7 (FBXO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 7 (FBXO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 7 (FBXO7) ELISA Kit Customized Service Offer
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  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
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  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma."Oncogene 22:298-307(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region."J. Biol. Chem. 279:32592-32602(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6."EMBO J. 24:3104-3116(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination."Biochem. Biophys. Res. Commun. 342:1022-1026(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor."J. Biol. Chem. 283:22325-22335(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy."Nat. Neurosci. 16:1257-1265(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction."Acta Crystallogr. D 70:155-164(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays."Am. J. Hum. Genet. 82:1375-1384(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability."Neurogenetics 12:33-39(2011) [PubMed] [Europe PMC] [Abstract]