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F-Box Protein 4 (FBXO4)

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FBX4

F-Box Protein 4 (FBXO4)
CCC F424
HGNC 13583
MGI 2146220
PubMed 22124152
RGD 1307580
UniProt Q9UKT5
Wiki FBXO4
F-box only protein 4 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 4 (FBXO4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 4 (FBXO4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 4 (FBXO4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 4 (FBXO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 4 (FBXO4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 4 (FBXO4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 4 (FBXO4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 4 (FBXO4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 4 (FBXO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 4 (FBXO4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box Protein 4 (FBXO4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box Protein 4 (FBXO4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box Protein 4 (FBXO4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box Protein 4 (FBXO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box Protein 4 (FBXO4) ELISA Kit Customized Service Offer
  1. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A family of mammalian F-box proteins."Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance."J. Biol. Chem. 281:759-768(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer."Cancer Cell 14:68-78(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Structural basis of selective ubiquitination of TRF1 by SCFFbx4."Dev. Cell 18:214-225(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase."J. Biol. Chem. 285:13896-13906(2010) [PubMed] [Europe PMC] [Abstract]