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Endothelin 2 (EDN2)

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ET2; PPET2; Preproendothelin-2

Endothelin 2 (EDN2)
CCC F415
HGNC 3177
MGI 95284
PubMed 18516093
RGD 2533
UniProt P20800
Wiki Endothelin_2
Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.
The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3 . Based on the deduced amino acid sequences of the cloned ET2 and ET3 genes, corresponding proteins have been chemically synthesized and their vasoconstrictor activities studied. Of the 3 isopeptides, ET-2 has the most potent vasoconstrictor activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF415Hu01 Recombinant Endothelin 2 (EDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF415Hu01 Polyclonal Antibody to Endothelin 2 (EDN2) WB; IHC; ICC; IP.
MAF415Hu21 Monoclonal Antibody to Endothelin 2 (EDN2) WB; IHC; ICC; IP.
Assay Kits CEF415Hu ELISA Kit for Endothelin 2 (EDN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endothelin 2 (EDN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endothelin 2 (EDN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endothelin 2 (EDN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endothelin 2 (EDN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endothelin 2 (EDN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF415Ra01 Recombinant Endothelin 2 (EDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF415Ra01 Polyclonal Antibody to Endothelin 2 (EDN2) WB; IHC; ICC; IP.
MAF415Ra21 Monoclonal Antibody to Endothelin 2 (EDN2) WB; IHC; ICC; IP.
Assay Kits CEF415Ra ELISA Kit for Endothelin 2 (EDN2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization."FEBS Lett. 274:136-140(1990) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2."Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2."J. Cardiovasc. Pharmacol. 17:S39-S43(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Proteolytic processing of big endothelin-3 by the kell blood group protein."Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]