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Engulfment And Cell Motility 1 (ELMO1)

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Protein ced-12 homolog

Engulfment And Cell Motility 1 (ELMO1)
CCC F400
HGNC 16286
MGI 2153044
PubMed 20844538
RGD 1308182
UniProt Q92556
Wiki ELMO1
Engulfment and cell motility protein 1 isinteracts with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Similarity to a C. elegans protein suggests that this protein may function in apoptosis and in cell migration. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In mammalian cells, ELMO1 functionally cooperated with CRKII and DOCK180 to promote phagocytosis and cell shape changes. Ced12/ELMO1 bound directly to Ced5/DOCK180. This evolutionarily conserved complex stimulated a Rac-GEF, leading to RAC1 activation and cytoskeletal rearrangements. These studies identified Ced12/ELMO as an upstream regulator of RAC1 that affects engulfment and cell migration from C. elegans to mammals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF400Hu01 Recombinant Engulfment And Cell Motility 1 (ELMO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Engulfment And Cell Motility 1 (ELMO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Engulfment And Cell Motility 1 (ELMO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Engulfment And Cell Motility 1 (ELMO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Engulfment And Cell Motility 1 (ELMO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Engulfment And Cell Motility 1 (ELMO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Engulfment And Cell Motility 1 (ELMO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Engulfment And Cell Motility 1 (ELMO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Engulfment And Cell Motility 1 (ELMO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Engulfment And Cell Motility 1 (ELMO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Engulfment And Cell Motility 1 (ELMO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Engulfment And Cell Motility 1 (ELMO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Engulfment And Cell Motility 1 (ELMO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Engulfment And Cell Motility 1 (ELMO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Engulfment And Cell Motility 1 (ELMO1) ELISA Kit Customized Service Offer
  1. "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration."Cell 107:27-41(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1."J. Biol. Chem. 277:28238-28246(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex."Nat. Cell Biol. 4:574-582(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck."Biochemistry 44:8841-8849(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells."Mol. Biol. Cell 18:4780-4793(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing."Am. J. Hum. Genet. 87:532-537(2010) [PubMed] [Europe PMC] [Abstract]