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Telomeric Repeat Binding Factor 2 (TERF2)

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TRBF2; TRF2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein

Telomeric Repeat Binding Factor 2 (TERF2)
CCC F384
HGNC 11729
MGI 1195972
PubMed 24701373
RGD 1310881
UniProt Q15554
Wiki TERF2
TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. TRF2 may protect chromosome ends by maintaining the correct structure at telomere termini. In addition, expression of mutant forms of TRF2 induced a growth arrest with characteristics of senescence. These results raise the possibility that chromosome end fusions and senescence in primary human cells may be caused by loss by TRF2 from shortened telomeres.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF384Hu01 Recombinant Telomeric Repeat Binding Factor 2 (TERF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF384Hu21 Monoclonal Antibody to Telomeric Repeat Binding Factor 2 (TERF2) WB; IHC; ICC; IP.
PAF384Hu01 Polyclonal Antibody to Telomeric Repeat Binding Factor 2 (TERF2) WB; ICC/IF
Assay Kits SEF384Hu ELISA Kit for Telomeric Repeat Binding Factor 2 (TERF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomeric Repeat Binding Factor 2 (TERF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomeric Repeat Binding Factor 2 (TERF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomeric Repeat Binding Factor 2 (TERF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomeric Repeat Binding Factor 2 (TERF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomeric Repeat Binding Factor 2 (TERF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomeric Repeat Binding Factor 2 (TERF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomeric Repeat Binding Factor 2 (TERF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomeric Repeat Binding Factor 2 (TERF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomeric Repeat Binding Factor 2 (TERF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomeric Repeat Binding Factor 2 (TERF2) ELISA Kit Customized Service Offer
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  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
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  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
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  30. "How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures."EMBO Rep. 6:39-45(2005) [PubMed] [Europe PMC] [Abstract]
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