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Cullin 2 (CUL2)

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Cullin 2 (CUL2)
CCC F362
HGNC 2552
MGI 1918995
PubMed 15601820
RGD 1310644
UniProt Q13617
Wiki CUL2
Kipreos et al. (1996) identified a conserved gene family, designated cullins, with at least 5 members in nematodes, 6 in humans, and 3 in S. cerevisiae. Human CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.
CUL2 specifically associates with the trimeric VHL-elongin B-elongin C, or VBC, complex in vitro and in vivo. This association was disrupted by mutations in VHL that disrupt elongin binding. Nearly 70% of the naturally-occurring cancer-disposing mutations in VHL abrogate elongin binding, suggesting that binding to elongin-CUL2 complexes contributes to the ability of VHL to suppress tumor growth in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF362Hu01 Recombinant Cullin 2 (CUL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cullin 2 (CUL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 2 (CUL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 2 (CUL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 2 (CUL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 2 (CUL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 2 (CUL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 2 (CUL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 2 (CUL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 2 (CUL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 2 (CUL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 2 (CUL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 2 (CUL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 2 (CUL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 2 (CUL2) ELISA Kit Customized Service Offer
  1. "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins."Proc. Natl. Acad. Sci. U.S.A. 94:2156-2161(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of NEDD8-conjugation site in human cullin-2."Biochem. Biophys. Res. Commun. 257:100-105(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family."Cell 85:829-839(1996) [PubMed] [Europe PMC] [Abstract]
  7. "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity."Mol. Cell 3:535-541(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex."Proc. Natl. Acad. Sci. U.S.A. 97:10430-10435(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase."J. Biol. Chem. 276:29748-29753(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase."Proc. Natl. Acad. Sci. U.S.A. 99:10353-10358(2002) [PubMed] [Europe PMC] [Abstract]
  11. "TIP120A associates with cullins and modulates ubiquitin ligase activity."J. Biol. Chem. 278:15905-15910(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Covalent modification of all members of human cullin family proteins by NEDD8."Oncogene 18:6829-6834(1999) [PubMed] [Europe PMC] [Abstract]
  13. "VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases."Genes Dev. 18:3055-3065(2004) [PubMed] [Europe PMC] [Abstract]
  14. "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase."J. Virol. 81:3428-3436(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5."Mol. Cell 48:692-704(2012) [PubMed] [Europe PMC] [Abstract]
  20. "The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."Nat. Cell Biol. 14:201-208(2012) [PubMed] [Europe PMC] [Abstract]