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Crystallin Zeta (CRYz)

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Quinone Oxidoreductase; Quinone Reductase; NADPH:quinone reductase

Crystallin Zeta (CRYz)
CCC F356
HGNC 2419
MGI 88527
PubMed 22843503
RGD 1311639
UniProt Q08257
Wiki CRYZ
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins.
CRYz encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.Only very low amounts in the lens.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Zeta (CRYz) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Zeta (CRYz) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Zeta (CRYz) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Zeta (CRYz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Zeta (CRYz) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Zeta (CRYz) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Zeta (CRYz) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Zeta (CRYz) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Zeta (CRYz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Zeta (CRYz) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Zeta (CRYz) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Zeta (CRYz) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Zeta (CRYz) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Zeta (CRYz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Zeta (CRYz) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver."Biochem. Biophys. Res. Commun. 191:902-907(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ)."Genomics 21:317-324(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human and yeast zeta-crystallins bind AU-rich elements in RNA."Cell. Mol. Life Sci. 64:1419-1427(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "{zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia."FASEB J. 24:1852-1865(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human zeta-crystallin at 1.85 A."Submitted (MAR-2007) to the PDB data bank