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Crystallin Gamma D (CRYgD)

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CACA; CCA3; CRYG4; Cry-g-D

Crystallin Gamma D (CRYgD)
CCC F351
HGNC 2411
MGI 88524
PubMed 17724170
RGD 2422
UniProt P07320
Wiki CRYGD
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma D (CRYgD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma D (CRYgD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma D (CRYgD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma D (CRYgD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma D (CRYgD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma D (CRYgD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma D (CRYgD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma D (CRYgD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma D (CRYgD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma D (CRYgD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma D (CRYgD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma D (CRYgD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma D (CRYgD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma D (CRYgD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma D (CRYgD) ELISA Kit Customized Service Offer
  1. "Structural and evolutionary relationships among five members of the human gamma-crystallin gene family."Mol. Cell. Biol. 5:1408-1414(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of human lens crystallins."Invest. Ophthalmol. Vis. Sci. 36:S882-S882(1995)
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin."Biochemistry 44:2491-2500(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract."J. Mol. Biol. 328:1137-1147(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins."Biochem. Biophys. Res. Commun. 300:624-630(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The gamma-crystallins and human cataracts: a puzzle made clearer."Am. J. Hum. Genet. 65:1261-1267(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Progressive juvenile-onset punctate cataracts caused by mutation of the gamma-D-crystallin gene."Proc. Natl. Acad. Sci. U.S.A. 96:1008-1012(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Link between a novel human gamma-D-crystallin allele and a unique cataract phenotype explained by protein crystallography."Hum. Mol. Genet. 9:1779-1786(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular basis of a progressive juvenile-onset hereditary cataract."Proc. Natl. Acad. Sci. U.S.A. 97:1993-1998(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal cataracts: human genetic cataract caused by protein crystallization."Proc. Natl. Acad. Sci. U.S.A. 98:6116-6120(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts."J. Med. Genet. 39:352-358(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts."J. Med. Genet. 40:262-267(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Two affected siblings with nuclear cataract associated with a novel missense mutation in the CRYGD gene."Mol. Vis. 12:995-1000(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state."Am. J. Hum. Genet. 81:32-43(2007) [PubMed] [Europe PMC] [Abstract]
  19. "A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family."Hum. Mutat. 32:E1939-E1947(2011) [PubMed] [Europe PMC] [Abstract]