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Crystallin Gamma C (CRYgC)

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CCL; CRYG3

Crystallin Gamma C (CRYgC)
CCC F350
HGNC 2410
MGI 88523
PubMed 24281366
RGD 2421
UniProt P07315
Wiki CRYGC
Interactions between mutated crystallins alpha-A (R116C), alpha-B (R120G), and gamma-C (T5P) and the corresponding wildtype proteins, as well as with wildtype beta-B2-crystallin and HSP27, were analyzed in a mammalian cell 2-hybrid system. For mutated alpha-A-crystallin, interactions with wildtype beta-B2-crystallin and gamma-C-crystallin decreased and those with wildtype alpha-B-crystallin and HSP27 increased.
For mutated alpha-B-crystallin, the interactions with wildtype alpha-A-crystallin and alpha-B-crystallin decreased, but those with wildtype beta-B2-crystallin and gamma-C-crystallin increased slightly. For mutated gamma-C-crystallin, most of the interactions were decreased.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma C (CRYgC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma C (CRYgC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma C (CRYgC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma C (CRYgC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma C (CRYgC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma C (CRYgC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma C (CRYgC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma C (CRYgC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma C (CRYgC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma C (CRYgC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma C (CRYgC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma C (CRYgC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma C (CRYgC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma C (CRYgC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma C (CRYgC) ELISA Kit Customized Service Offer
  1. "Two human gamma-crystallin genes are linked and riddled with Alu-repeats."Gene 38:197-204(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Structural and evolutionary relationships among five members of the human gamma-crystallin gene family."Mol. Cell. Biol. 5:1408-1414(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region."Gene 78:201-213(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of human lens crystallins."Invest. Ophthalmol. Vis. Sci. 36:S882-S882(1995)
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Methylation and carbamylation of human gamma-crystallins."Protein Sci. 12:1762-1774(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A nonsense mutation of CRYGC associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree."Mol. Vis. 18:1874-1880(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins."Biochem. Biophys. Res. Commun. 300:624-630(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The gamma-crystallins and human cataracts: a puzzle made clearer."Am. J. Hum. Genet. 65:1261-1267(1999) [PubMed] [Europe PMC] [Abstract]
  12. ErratumAm. J. Hum. Genet. 66:753-753(2000)
  13. "A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract."Hum. Genet. 106:531-537(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts."J. Med. Genet. 39:352-358(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Alteration of protein-protein interactions of congenital cataract crystallin mutants."Invest. Ophthalmol. Vis. Sci. 44:1155-1159(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Mutation screening and genotype phenotype correlation of alpha-crystallin, gamma-crystallin and GJA8 gene in congenital cataract."Mol. Vis. 17:693-707(2011) [PubMed] [Europe PMC] [Abstract]
  17. "A novel mutation impairing the tertiary structure and stability of gammaC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens."Hum. Mutat. 33:391-401(2012) [PubMed] [Europe PMC] [Abstract]