≡

Crystallin Gamma B (CRYgB)

[Edit]

CRYG2

Crystallin Gamma B (CRYgB)
CCC F349
HGNC 2409
MGI 88522
PubMed 19384013
RGD 1584991
UniProt P07316
Wiki CRYGB
Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. Den Dunnen et al. (1985) isolated a genomic cosmid clone containing 2 closely linked gamma-crystallin genes, CRYGB and CRYGC, oriented in the same direction. They sequenced the coding regions of the genes as well as their 5-prime and 3-prime flanking regions. The genes share 80% homology.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma B (CRYgB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma B (CRYgB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma B (CRYgB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma B (CRYgB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma B (CRYgB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma B (CRYgB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma B (CRYgB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma B (CRYgB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma B (CRYgB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma B (CRYgB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Gamma B (CRYgB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Gamma B (CRYgB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Gamma B (CRYgB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Gamma B (CRYgB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Gamma B (CRYgB) ELISA Kit Customized Service Offer
  1. "Two human gamma-crystallin genes are linked and riddled with Alu-repeats."Gene 38:197-204(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region."Gene 78:201-213(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Novel crystallin gamma B mutations in a Kuwaiti family with autosomal dominant congenital cataracts reveal genetic and clinical heterogeneity."Mol. Vis. 18:2931-2936(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins."Biochem. Biophys. Res. Commun. 300:624-630(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Prediction of possible sites for posttranslational modifications in human gamma crystallins: effect of glycation on the structure of human gamma-B-crystallin as analyzed by molecular modeling."Proteins 53:162-173(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein."J. Mol. Biol. 372:172-185(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts."J. Med. Genet. 39:352-358(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts."J. Med. Genet. 40:262-267(2003) [PubMed] [Europe PMC] [Abstract]