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Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins.
CRYbA1, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Crystallin Beta A1 (CRYbA1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Crystallin Beta A1 (CRYbA1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Crystallin Beta A1 (CRYbA1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Crystallin Beta A1 (CRYbA1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Crystallin Beta A1 (CRYbA1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF342Mu01 | Recombinant Crystallin Beta A1 (CRYbA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAF342Mu01 | Polyclonal Antibody to Crystallin Beta A1 (CRYbA1) | WB; IHC; ICC; IP. |
| Assay Kits | SEF342Mu | ELISA Kit for Crystallin Beta A1 (CRYbA1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Crystallin Beta A1 (CRYbA1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Crystallin Beta A1 (CRYbA1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Crystallin Beta A1 (CRYbA1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Crystallin Beta A1 (CRYbA1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Crystallin Beta A1 (CRYbA1) | ELISA Kit Customized Service Offer |
- "Characterization of the human beta-crystallin gene Hu beta A3/A1 reveals ancestral relationships among the beta gamma-crystallin superfamily."J. Biol. Chem. 261:12420-12427(1986) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]
- "Autosomal dominant zonular cataract with sutural opacities is associated with a splice mutation in the betaA3/A1-crystallin gene."Mol. Vis. 4:21-21(1998) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the G91del CRYBA1/3-crystallin protein: a cause of human inherited cataract."Hum. Mol. Genet. 13:945-953(2004) [PubMed] [Europe PMC] [Abstract]
- "Modifications of human betaA1/betaA3-crystallins include S-methylation, glutathiolation, and truncation."Protein Sci. 14:45-54(2005) [PubMed] [Europe PMC] [Abstract]