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Carboxypeptidase A6 (CPA6)

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CPAH

Carboxypeptidase A6 (CPA6)
CCC F319
HGNC 17245
MGI 3045348
PubMed 24290490
RGD 1311764
UniProt Q8N4T0
Wiki CPA6
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA6, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme.
The deduced 437-amino acid protein contains an N-terminal signal peptide, followed by a pro domain and a carboxypeptidase catalytic domain that includes residues involved in zinc coordination and substrate catalysis. RT-PCR analysis detected CPA6 expression in human fetal umbilical cord blood and in mouse brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A6 (CPA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A6 (CPA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A6 (CPA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A6 (CPA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A6 (CPA6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A6 (CPA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A6 (CPA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A6 (CPA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A6 (CPA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A6 (CPA6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase A6 (CPA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase A6 (CPA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase A6 (CPA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase A6 (CPA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase A6 (CPA6) ELISA Kit Customized Service Offer
  1. "Identification and characterization of three members of the human metallocarboxypeptidase gene family."J. Biol. Chem. 277:14954-14964(2002) [PubMed] [Europe PMC] [Abstract]
  2. "A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient."Invest. Ophthalmol. Vis. Sci. 43:3609-3612(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of carboxypeptidase A6, an extracellular matrix peptidase."J. Biol. Chem. 283:7054-7063(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Substrate specificity of human carboxypeptidase A6."J. Biol. Chem. 285:38234-38242(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy."Hum. Mutat. 33:124-135(2012) [PubMed] [Europe PMC] [Abstract]