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Coatomer Protein Complex Subunit Beta 1 (COPb1)

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Beta-COP; Beta-coat protein

Coatomer Protein Complex Subunit Beta 1 (COPb1)
CCC F309
HGNC 2231
MGI 1917599
PubMed 17698811
RGD 620861
UniProt P53618
Wiki COPB1
COPb1 encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described.These adaptor complexes contain a number of components, including the alpha-, beta-, and gamma-adaptins. A similar set of proteins, namely, alpha-COP (160 kD), beta-COP (110 kD), gamma-COP (98 kD), and delta-COP (61 kD), is associated with the non-clathrin-coated vesicles, which have been suggested to be involved in intra-Golgi transport and transport from the ER to the Golgi complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF309Hu01 Recombinant Coatomer Protein Complex Subunit Beta 1 (COPb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Coatomer Protein Complex Subunit Beta 1 (COPb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coatomer Protein Complex Subunit Beta 1 (COPb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coatomer Protein Complex Subunit Beta 1 (COPb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coatomer Protein Complex Subunit Beta 1 (COPb1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coatomer Protein Complex Subunit Beta 1 (COPb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coatomer Protein Complex Subunit Beta 1 (COPb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coatomer Protein Complex Subunit Beta 1 (COPb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coatomer Protein Complex Subunit Beta 1 (COPb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coatomer Protein Complex Subunit Beta 1 (COPb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coatomer Protein Complex Subunit Beta 1 (COPb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coatomer Protein Complex Subunit Beta 1 (COPb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coatomer Protein Complex Subunit Beta 1 (COPb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coatomer Protein Complex Subunit Beta 1 (COPb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coatomer Protein Complex Subunit Beta 1 (COPb1) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic."J. Biol. Chem. 269:30073-30076(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex."Am. J. Hum. Genet. 57:817-823(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of novel isoforms of COP I subunits."J. Biochem. 128:793-801(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP."Traffic 8:582-593(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1."Am. J. Physiol. 294:C1485-C1498(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic."J. Biol. Chem. 283:22774-22786(2008) [PubMed] [Europe PMC] [Abstract]
  9. "HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells."PLoS Pathog. 4:E1000131-E1000131(2008) [PubMed] [Europe PMC] [Abstract]
  10. "COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro."Proc. Natl. Acad. Sci. U.S.A. 105:5254-5259(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Early endosomes and endosomal coatomer are required for autophagy."J. Cell Biol. 185:305-321(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP."Biochem. Biophys. Res. Commun. 395:244-250(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly."J. Biol. Chem. 285:7197-7207(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport."J. Cell Sci. 127:2825-2839(2014) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]