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Centrin 2 (CETN2)

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CALT; CEN2; Caltractin; Centrin EF-Hand Protein 2; Caltractin isoform 1

Centrin 2 (CETN2)
CCC F280
HGNC 1867
MGI 1347085
PubMed 22825473
RGD 620247
UniProt P41208
Wiki CETN2
Caltractin, a 20-kD calcium-binding protein, was purified and cloned at the DNA level from the unicellular green alga Chlamydomonas. It showed a strong amino acid sequence relatedness (50%) to the CDC31 gene product from Saccharomyces cerevisiae. Examination of mutants in Chlamydomonas caltractin and yeast CDC31 indicated that these proteins are required for the proper duplication and segregation of the centrosome (major microtubule-organizing center; MTOC) in these cells. The full-length human cDNA, which they isolated from a T-cell lymphoblastic leukemia cDNA library, encodes a deduced 72-amino acid protein with 4 potential EF-hand calcium-binding domains. The protein shares 70% sequence identity with its algal counterpart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF280Hu01 Recombinant Centrin 2 (CETN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF280Hu01 Polyclonal Antibody to Centrin 2 (CETN2) WB; IHC; ICC; IP.
Assay Kits SEF280Hu ELISA Kit for Centrin 2 (CETN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrin 2 (CETN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrin 2 (CETN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrin 2 (CETN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrin 2 (CETN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrin 2 (CETN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrin 2 (CETN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrin 2 (CETN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrin 2 (CETN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrin 2 (CETN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrin 2 (CETN2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and centrosomal localization of human caltractin."Proc. Natl. Acad. Sci. U.S.A. 90:11039-11043(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative genome sequence analysis of the Bpa/Str region in mouse and man." Genome Res. 10:758-775(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair."J. Biol. Chem. 276:18665-18672(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Centrin-2 is required for centriole duplication in mammalian cells."Curr. Biol. 12:1287-1292(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Calcium-dependent self-assembly of human centrin 2."J. Biol. Chem. 279:47672-47680(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein."Mol. Cell. Biol. 25:5664-5674(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein."Biochemistry 45:14965-14979(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Binding of human centrin 2 to the centrosomal protein hSfi1."FEBS J. 273:4504-4515(2006) [PubMed] [Europe PMC] [Abstract]
  13. "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability."Mol. Biol. Cell 17:3423-3434(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export."Nucleic Acids Res. 40:4562-4573(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain."Biochemistry 42:1439-1450(2003) [PubMed] [Europe PMC] [Abstract]
  22. "The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly."Biochemistry 45:880-889(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair."Biochemistry 45:3653-3663(2006) [PubMed] [Europe PMC] [Abstract]
  24. "The structure of the human centrin 2-xeroderma pigmentosum group C protein complex."J. Biol. Chem. 281:18746-18752(2006) [PubMed] [Europe PMC] [Abstract]