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Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2)

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Stargazin; Transmembrane AMPAR regulatory protein gamma-2; Neuronal voltage-gated calcium channel gamma-2 subunit

Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2)
CCC F248
HGNC 1406
MGI 1316660
PubMed 20688780
RGD 71095
UniProt Q9Y698
Wiki CACNG2
L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures.
CACNg2is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family.The deduced 315-amino acid CACNG2 transmembrane protein is 98% identical to CACNG3 and mouse Cacng2, but only 18% identical to CACNG1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2) ELISA Kit Customized Service Offer
  1. "Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications."Mayo Clin. Proc. 74:357-361(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating."Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability." Am. J. Hum. Genet. 88:306-316(2011) [PubMed] [Europe PMC] [Abstract]