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Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2)

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CACNA2D; LUAC11.1

Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2)
CCC F246
HGNC 1400
MGI 1929813
PubMed 12555074
RGD 631360
UniProt Q9NY47
Wiki CACNA2D2
Calcium Channel,Voltage Dependent,Alpha 2/Delta Subunit 2 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex.
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Alpha 2/Delta Subunit 2 (CACNa2d2) ELISA Kit Customized Service Offer
  1. "Molecular diversity of the calcium channel alpha2delta subunit."J. Neurosci. 19:684-691(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)."J. Biol. Chem. 275:12237-12242(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit."Eur. J. Neurosci. 12:1217-1226(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes."J. Membr. Biol. 184:35-43(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Calcium channel alpha2delta subunits: differential expression, function, and drug binding."J. Bioenerg. Biomembr. 35:639-647(2003) [PubMed] [Europe PMC] [Abstract]
  9. "CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity."Oncogene 22:615-626(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Modulation of gating currents of the Ca(v)3.1 calcium channel by alpha 2 delta 2 and gamma 5 subunits."Arch. Biochem. Biophys. 425:207-213(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]