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Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C)

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CACH2; CACN2; CACNL1A1; CCHL1A1; CaV1.2; TS; Voltage-gated calcium channel subunit alpha Cav1.2; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle

Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C)
CCC F236
HGNC 1390
MGI 103013
PubMed 18711365
RGD 2245
UniProt Q13936
Wiki CACNA1C
Activation of voltage-sensitive calcium channels by membrane depolarization triggers key cellular responses such as contraction, secretion, excitation, and electrical signaling. The L-type currents produced by voltage-sensitive calcium channels are blocked by 1,4-dihydropyridine (DHP) derivatives; thus, the channels responsible for these currents are referred to as DHP-sensitive. The skeletal muscle DHP-sensitive calcium channel is a complex of 5 subunits: alpha-1, alpha-2, beta, gamma, and delta. The DHP-sensitive calcium channels from cardiac muscle and the brain have pharmacologic and electrophysiologic properties that differ from those of the skeletal muscle channel. Powers et al. (1991) isolated a clone for the human CCHL1A1 gene and partially sequenced it.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Polyclonal Antibody Customized Service Offer
Assay Kits SEF236Hu ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF236Mu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Positive Control; Immunogen; SDS-PAGE; WB.
RPF236Mu02 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF236Mu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) WB; IHC; ICC; IP.
PAF236Mu02 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) WB; IHC; ICC; IP.
Assay Kits SEF236Mu ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit (CACNa1C) ELISA Kit Customized Service Offer
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  5. "Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit."Am. J. Physiol. 272:H1372-H1381(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular structures involved in L-type calcium channel inactivation. Role of the carboxyl-terminal region encoded by exons 40-42 in alpha1C subunit in the kinetics and Ca2+ dependence of inactivation."J. Biol. Chem. 272:3560-3566(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene."FEBS Lett. 427:220-224(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation."Am. J. Physiol. 283:C1001-C1008(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit."Proc. Natl. Acad. Sci. U.S.A. 103:17024-17029(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C."J. Biol. Chem. 277:3419-3423(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."J. Biol. Chem. 265:20430-20436(1990) [PubMed] [Europe PMC] [Abstract]
  14. "Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter."Genomics 10:835-839(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter."Genomics 14:1092-1094(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel."J. Biol. Chem. 268:13026-13029(1993) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit."Mol. Pharmacol. 62:485-496(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels."J. Neurosci. 24:4698-4708(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1."J. Biol. Chem. 280:29612-29619(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain."Nature 429:671-675(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism."Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations."Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death." Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Novel Timothy syndrome mutation leading to increase in CACNA1C window current."Heart Rhythm 12:211-219(2015) [PubMed] [Europe PMC] [Abstract]