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Angiomotin Like Protein 1 (AMOTL1)

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JEAP; Junction-Enriched And Associated Protein

Angiomotin Like Protein 1 (AMOTL1)
CCC F211
HGNC 17811
MGI 1922973
PubMed 21224387
RGD 1305268
UniProt Q8IY63
Wiki AMOTL1
Angiomotin-like protein 1 is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.
In the presence of angiostatin, endothelial cells that overexpress angiomotin exhibit a significant reduction in migration toward growth factors as well as an inability to form tubules in vitro. These observations are consistent with the localization of angiomotin in the leading edge of migrating cells. Angiostatin, therefore, disrupts the normal migratory function of Angiomotin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF211Hu01 Recombinant Angiomotin Like Protein 1 (AMOTL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF211Hu01 Polyclonal Antibody to Angiomotin Like Protein 1 (AMOTL1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Angiomotin Like Protein 1 (AMOTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiomotin Like Protein 1 (AMOTL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF211Mu01 Recombinant Angiomotin Like Protein 1 (AMOTL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Angiomotin Like Protein 1 (AMOTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiomotin Like Protein 1 (AMOTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiomotin Like Protein 1 (AMOTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiomotin Like Protein 1 (AMOTL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiomotin Like Protein 1 (AMOTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiomotin Like Protein 1 (AMOTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiomotin Like Protein 1 (AMOTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiomotin Like Protein 1 (AMOTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiomotin Like Protein 1 (AMOTL1) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains."Gene 298:69-77(2002) [PubMed] [Europe PMC] [Abstract]
  5. ErratumGene 310:231-231(2003)
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation."Biochem. J. 444:279-289(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish."J. Biol. Chem. 287:13005-13015(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]