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Angiomotin Like Protein 2 (AMOTL2)

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LCCP; Leman Coiled-Coil Protein

Angiomotin Like Protein 2 (AMOTL2)
CCC F210
HGNC 17812
MGI 1929286
PubMed 17293535
RGD 70977
UniProt Q9Y2J4
Wiki AMOTL2
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. AMOTL2 encoded by this gene is related to angiomotin and is a member of the motins protein family.
In the presence of angiostatin, endothelial cells that overexpress angiomotin exhibit a significant reduction in migration toward growth factors as well as an inability to form tubules in vitro. These observations are consistent with the localization of angiomotin in the leading edge of migrating cells. Angiostatin, therefore, disrupts the normal migratory function of Angiomotin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF210Hu01 Recombinant Angiomotin Like Protein 2 (AMOTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Angiomotin Like Protein 2 (AMOTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiomotin Like Protein 2 (AMOTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiomotin Like Protein 2 (AMOTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiomotin Like Protein 2 (AMOTL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiomotin Like Protein 2 (AMOTL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiomotin Like Protein 2 (AMOTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiomotin Like Protein 2 (AMOTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiomotin Like Protein 2 (AMOTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiomotin Like Protein 2 (AMOTL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiomotin Like Protein 2 (AMOTL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiomotin Like Protein 2 (AMOTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiomotin Like Protein 2 (AMOTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiomotin Like Protein 2 (AMOTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiomotin Like Protein 2 (AMOTL2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains."Gene 298:69-77(2002) [PubMed] [Europe PMC] [Abstract]
  4. ErratumGene 310:231-231(2003)
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation."Development 134:979-988(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis."J. Biol. Chem. 286:41095-41104(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish."J. Biol. Chem. 287:13005-13015(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]