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Adducin 2 (ADD2)

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ADDB; Beta-Adducin; Erythrocyte adducin subunit beta

Adducin 2 (ADD2)
CCC F204
HGNC 244
MGI 87919
PubMed 15963851
RGD 2042
UniProt P35612
Wiki ADD2
Beta-adducin is a protein encoded by the ADD2 gene. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adducin 2 (ADD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adducin 2 (ADD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adducin 2 (ADD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adducin 2 (ADD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adducin 2 (ADD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adducin 2 (ADD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adducin 2 (ADD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adducin 2 (ADD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adducin 2 (ADD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adducin 2 (ADD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adducin 2 (ADD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adducin 2 (ADD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adducin 2 (ADD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adducin 2 (ADD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adducin 2 (ADD2) ELISA Kit Customized Service Offer
  1. "Primary structure and domain organization of human alpha and beta adducin."J. Cell Biol. 115:665-675(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants."Biochem. Biophys. Res. Commun. 309:359-367(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A novel isoform of beta adducin utilizes an alternatively spliced exon near the C-terminus."Mol. Biol. Cell 6:269-269(1995)
  8. "Genomic organisation and chromosomal localisation of the gene encoding human beta adducin."Gene 167:313-316(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C."J. Biol. Chem. 271:25157-25166(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1."J. Biol. Chem. 283:14600-14609(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]