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Tight Junction Protein 2 (TJP2)

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X104; ZO-2; ZO2; Zona Occludens 2; Friedreich Ataxia Region Gene X104; Zona occludens protein 2; Zonula occludens protein 2

Tight Junction Protein 2 (TJP2)
CCC F167
HGNC 11828
MGI 1341872
PubMed 12704386
RGD 619807
UniProt Q9UDY2
Wiki TJP2
TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants. This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain whereas isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. In brain and skeletal muscle, only isoform A1 is detectable. Isoform C1 is found in normal as well as in most neoplastic tissues while isoform A1 is present almost exclusively in normal tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF167Hu01 Recombinant Tight Junction Protein 2 (TJP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF167Hu21 Monoclonal Antibody to Tight Junction Protein 2 (TJP2) WB; IHC; ICC; IP.
PAF167Hu01 Polyclonal Antibody to Tight Junction Protein 2 (TJP2) WB; IHC; ICC/IF
Assay Kits SEF167Hu ELISA Kit for Tight Junction Protein 2 (TJP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tight Junction Protein 2 (TJP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tight Junction Protein 2 (TJP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tight Junction Protein 2 (TJP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tight Junction Protein 2 (TJP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tight Junction Protein 2 (TJP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tight Junction Protein 2 (TJP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tight Junction Protein 2 (TJP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tight Junction Protein 2 (TJP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tight Junction Protein 2 (TJP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tight Junction Protein 2 (TJP2) ELISA Kit Customized Service Offer
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  20. "Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins."J. Biol. Chem. 282:35988-35999(2007) [PubMed] [Europe PMC] [Abstract]
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  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]