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Exportin 4 (XPO4)

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Exp4

Exportin 4 (XPO4)
CCC F161
HGNC 17796
MGI 1888526
PubMed 10944119
RGD 1312015
UniProt Q9C0E2
XPO4 belongs to a large family of karyopherins that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.
The 3-prime UTR contains a repetitive sequence, and the 1,150-amino acid protein shares 99% amino acid identity with mouse Xpo4. RT-PCR ELISA detected high to moderate expression in all human tissues and specific brain regions examined. human XPO4 interacted with Smad3 via the Smad3 MH2 domain. RNAi knockdown of XPO4 blocked Smad3 export, as did addition of competing short peptides representing the Smad3-XPO4 interaction domain. In vivo and in vitro assays showed that XPO4 mediated nuclear export of Smad3 in a RanGTPase-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF161Hu01 Recombinant Exportin 4 (XPO4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF161Hu01 Polyclonal Antibody to Exportin 4 (XPO4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Exportin 4 (XPO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exportin 4 (XPO4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exportin 4 (XPO4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exportin 4 (XPO4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exportin 4 (XPO4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exportin 4 (XPO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exportin 4 (XPO4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exportin 4 (XPO4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exportin 4 (XPO4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exportin 4 (XPO4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exportin 4 (XPO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exportin 4 (XPO4) ELISA Kit Customized Service Offer
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  7. "The mechanism of nuclear export of Smad3 involves exportin 4 and Ran."Mol. Cell. Biol. 26:1318-1332(2006) [PubMed] [Europe PMC] [Abstract]
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  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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