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Exportin 5 (XPO5)

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RANBP21; Exp5; Ran-binding protein 21

Exportin 5 (XPO5)
CCC F160
HGNC 17675
MGI 1913789
PubMed 11777942
UniProt Q9HAV4
Wiki XPO5
Exportin-5 belongs to a large family of karyopherins that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments. The deduced 1,205-amino acid protein has a calculated molecular mass of about 136 kD. XPO5 and XPO1 share 25% amino acid identity.
Northern blot analysis detected transcripts of about 3.6 and 5.0 kb in all tissues examined.XPO5 bound the nucleoporins NUP214 and NUP153 in a RAN-GTP-independent manner and bound a cargo protein, ILF3, in a RAN-GTP-dependent manner. XPO5 bound ILF3 at its double-stranded RNA-binding domain (dsRBD) and also bound the dsRBDs of other proteins. XPO5 directly interacted with VA1 RNA in a RAN-GTP-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF160Hu01 Recombinant Exportin 5 (XPO5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF160Hu01 Polyclonal Antibody to Exportin 5 (XPO5) WB
MAF160Hu21 Monoclonal Antibody to Exportin 5 (XPO5) WB; IHC; ICC; IP.
Assay Kits SEF160Hu ELISA Kit for Exportin 5 (XPO5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exportin 5 (XPO5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exportin 5 (XPO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exportin 5 (XPO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exportin 5 (XPO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exportin 5 (XPO5) ELISA Kit Customized Service Offer
  1. "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm."EMBO J. 21:6205-6215(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins."J. Cell Biol. 156:53-64(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]