Ubiquitin Specific Peptidase 2 (USP2)

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UBP41; Ubiquitin carboxyl-terminal hydrolase 2; Ubiquitin Specific Protease 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2

Ubiquitin Specific Peptidase 2 (USP2)
Ubiquitin, a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).
Using a double-screening method of bacteria expressing chick skeletal muscle cDNA, Baek et al. (1997) isolated a cDNA encoding a deduced 357-amino acid protein expressing deubiquitinating activity. Because SDS-PAGE analysis indicated a 41-kD purified protein, the authors termed the protein Ubp41. The International Radiation Hybrid Mapping Consortium mapped the USP2 gene to chromosome 11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF142Hu01 Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF142Mu01 Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF142Mu01 Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 2 (USP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2."EMBO J. 26:976-986(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Suppression of cancer cell growth by promoting cyclin D1 degradation."Mol. Cell 36:469-476(2009) [PubMed] [Europe PMC] [Abstract]
  6. "MdmX is a substrate for the deubiquitinating enzyme USP2a."Oncogene 29:432-441(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of USP2-69 in mesangial cells in vivo and in vitro."Pathol. Int. 60:184-192(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Covalent ubiquitin-usp2 complex."Submitted (FEB-2009) to the PDB data bank
  9. "Structural basis of ubiquitin recognition by the deubiquitinating protease USP2."Structure 14:1293-1302(2006) [PubMed] [Europe PMC] [Abstract]