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Ubiquitin Specific Peptidase 16 (USP16)

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UBP-M; Ubiquitin Specific Protease 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin carboxyl-terminal hydrolase 16

Ubiquitin Specific Peptidase 16 (USP16)
CCC F136
HGNC 12614
MGI 1921362
PubMed 24025767
RGD 1307192
UniProt Q9Y5T5
Wiki USP16
USP16encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The 823-amino acid USP16 protein shares sequence similarities with other USPs and was shown to cleave standard substrates in vitro. Northern blot analysis detected a 3-kb transcript in all tissues tested. USP16 is maximally phosphorylated before metaphase and dephosphorylated in anaphase. Immunofluorescence microscopy showed that USP16 localizes to the cytoplasm and is expressed diffusely during mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 16 (USP16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 16 (USP16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 16 (USP16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 16 (USP16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 16 (USP16) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 16 (USP16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 16 (USP16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 16 (USP16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 16 (USP16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 16 (USP16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 16 (USP16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 16 (USP16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 16 (USP16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 16 (USP16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 16 (USP16) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli."Cell Death Differ. 8:1182-1196(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of cell cycle progression and gene expression by H2A deubiquitination."Nature 449:1068-1072(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes."BMC Cancer 8:299-299(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Usp16 contributes to somatic stem-cell defects in Down's syndrome."Nature 501:380-384(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin."J. Mol. Biol. 370:290-302(2007) [PubMed] [Europe PMC] [Abstract]