Heterogeneous Nuclear Ribonucleoprotein L (HNRPL)

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hnRNP-L; hnRNPL

Heterogeneous Nuclear Ribonucleoprotein L (HNRPL)
Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heterogeneous Nuclear Ribonucleoprotein L (HNRPL) ELISA Kit Customized Service Offer
  1. "Molecular basis of T cell-mediated recognition of pancreatic cancer cells."Cancer Res. 61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts."J. Cell Biol. 109:2575-2587(1989) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter."Nucleic Acids Res. 30:823-829(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL."Science 321:686-691(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo."J. Biol. Chem. 284:15701-15707(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Auto- and cross-regulation of the hnRNP L proteins by alternative splicing."Mol. Cell. Biol. 29:1442-1451(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels."J. Biol. Chem. 287:22709-22716(2012) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation."J. Biol. Chem. 288:22636-22649(2013) [PubMed] [Europe PMC] [Abstract]