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Splicing Factor 3B Subunit 1 (SF3B1)

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PRP10; PRPF10; SAP155; SF3b155; Spliceosome-associated protein 155; Pre-mRNA-splicing factor SF3b 155 kDa subunit

Splicing Factor 3B Subunit 1 (SF3B1)
CCC F113
HGNC 10768
MGI 1932339
PubMed 21998214
RGD 620148
UniProt O75533
Wiki SF3B1
Splicing factor 3B subunit 1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF113Hu01 Recombinant Splicing Factor 3B Subunit 1 (SF3B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Splicing Factor 3B Subunit 1 (SF3B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 3B Subunit 1 (SF3B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 3B Subunit 1 (SF3B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 3B Subunit 1 (SF3B1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 3B Subunit 1 (SF3B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 3B Subunit 1 (SF3B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 3B Subunit 1 (SF3B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 3B Subunit 1 (SF3B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 3B Subunit 1 (SF3B1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 3B Subunit 1 (SF3B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 3B Subunit 1 (SF3B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 3B Subunit 1 (SF3B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 3B Subunit 1 (SF3B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 3B Subunit 1 (SF3B1) ELISA Kit Customized Service Offer
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  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
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  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination."Mol. Cell 42:794-805(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth."Genes Dev. 27:615-626(2013) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of a core spliceosomal protein interface."Proc. Natl. Acad. Sci. U.S.A. 103:1266-1271(2006) [PubMed] [Europe PMC] [Abstract]
  26. "U2AF-homology motif interactions are required for alternative splicing regulation by SPF45."Nat. Struct. Mol. Biol. 14:620-629(2007) [PubMed] [Europe PMC] [Abstract]
  27. "NMR solution structure of the human spliceosomal protein complex p14-SF3B155."Submitted (JAN-2007) to the PDB data bank
  28. "Structural model of the p14/SF3b155 - branch duplex complex."RNA 17:155-165(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Cancer-relevant splicing factor CAPERalpha engages the essential splicing factor SF3b155 in a specific ternary complex."J. Biol. Chem. 289:17325-17337(2014) [PubMed] [Europe PMC] [Abstract]