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Serine/Arginine Rich Splicing Factor 3 (SRSF3)

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SFRS3; SRp20; Pre-mRNA-splicing factor SRP20; Splicing factor, arginine/serine-rich 3

Serine/Arginine Rich Splicing Factor 3 (SRSF3)
CCC F103
HGNC 10785
MGI 98285
PubMed 23299886
RGD 1309233
UniProt P84103
The SR family of mRNA splicing factors was so designated because SR proteins contain sequences of consecutive serine (S) and arginine (R) dipeptides. By searching a sequence database with the partial protein sequence of SRp20, the authors found that a previously identified cDNA, X16, encoded mouse SRp20.
The predicted 164-amino acid mouse and human proteins are identical. The sequence of the SRp20 protein is related to those of the other SR proteins identified; all contain 1 or 2 copies of an N-terminal repeat (A and B) spaced by a series of glycine residues that may form a flexible hinge, followed by a C-terminal SR domain. The A repeat contains an RNA recognition motif (RRM). SRp20 and SRp30b contain repeat A only.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 3 (SRSF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 3 (SRSF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 3 (SRSF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 3 (SRSF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 3 (SRSF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 3 (SRSF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 3 (SRSF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 3 (SRSF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 3 (SRSF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 3 (SRSF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 3 (SRSF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 3 (SRSF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 3 (SRSF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 3 (SRSF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 3 (SRSF3) ELISA Kit Customized Service Offer
  1. "SR proteins: a conserved family of pre-mRNA splicing factors."Genes Dev. 6:837-847(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein."Mol. Cell. Biol. 20:3049-3057(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA."Mol. Cell 7:899-905(2001) [PubMed] [Europe PMC] [Abstract]
  7. "SR splicing factors serve as adapter proteins for TAP-dependent mRNA export."Mol. Cell 11:837-843(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis."Int. J. Androl. 27:328-334(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization."J. Biol. Chem. 279:35788-35797(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP."Proc. Natl. Acad. Sci. U.S.A. 105:5154-5159(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8."EMBO J. 25:5126-5137(2006) [PubMed] [Europe PMC] [Abstract]