Serine/Arginine Rich Splicing Factor 2 (SRSF2)

SFRS2 contains a ribonucleoprotein (RNP)-type RNA-binding motif and a carboxyl-terminal serine/arginine-rich (SR) domain.in every member of the human SR family of splicing regulators, highly or ultraconserved elements are alternatively spliced, either as alternative 'poison cassette exons' containing early in-frame stop codons, or as alternative introns in the 3-prime untranslated region. These alternative splicing events target the resulting mRNAs for degradation by means of an RNA surveillance pathway called nonsense-mediated mRNA decay. Mouse orthologs of the human SR proteins exhibit the same unproductive splicing patterns. Three SR proteins, SRp20, SC35, and 9G8 (SFRS7), had been previously shown to direct splicing of their own transcripts, and SC35 autoregulates its expression by coupling alternative splicing with decay.