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Mediator Complex Subunit 15 (MED15)

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PCQAP; TIG1; ARC105; CAG7A; CTG7A; TIG-1; TNRC7; Trinucleotide Repeat Containing 7; PC2(Positive Cofactor 2,Multiprotein Complex)Glutamine/Q-Rich-Associated Protein

Mediator Complex Subunit 15 (MED15)
CCC F095
HGNC 14248
MGI 2137379
PubMed 2685570
RGD 1307560
UniProt Q96RN5
Wiki MED15
MED15 is a subunit of the multiprotein Mediator transcription complex (previously known as PC2, ARC, or DRIP) and may function as a transcriptional coactivator in RNA polymerase II transcription. MED15 cooperates with SREBP to regulate sterol responsive gene expression, and this regulatory action is conserved in the genetic model organism C. elegans, a roundworm (homologues MDT-15 and SBP-1). Also in C. elegans, MDT-15 is essential for the response to several stresses (fasting, heavy metal, toxin, and oxidative stress); at least in part the fasting response is conferred by interactions of MDT-15 with nuclear receptors, including NHR-49.The MED15 gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge's syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 15 (MED15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 15 (MED15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 15 (MED15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 15 (MED15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 15 (MED15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 15 (MED15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 15 (MED15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 15 (MED15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 15 (MED15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 15 (MED15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 15 (MED15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 15 (MED15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 15 (MED15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 15 (MED15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 15 (MED15) ELISA Kit Customized Service Offer
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  2. "Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit."Genomics 74:320-332(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling."Nature 418:641-646(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  10. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  11. "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system."FEBS Lett. 580:4784-4792(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Genome-wide location of the coactivator mediator: binding without activation and transient Cdk8 interaction on DNA."Mol. Cell 22:179-192(2006) [PubMed] [Europe PMC] [Abstract]
  13. "TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal."Nat. Cell Biol. 10:837-848(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis."Nature 442:700-704(2006) [PubMed] [Europe PMC] [Abstract]