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Mediator Complex Subunit 14 (MED14)

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CSRP; CRSP2; CRSP150; CXorf4; DRIP150; EXLM1; MED14; RGR1; TRAP170; Cofactor required for Sp1 transcriptional activation subunit 2; Vitamin D3 receptor-interacting 150 kDa

Mediator Complex Subunit 14 (MED14)
CCC F094
HGNC 2370
MGI 1349442
PubMed 9598311
RGD 1560170
UniProt O60244
Wiki MED14
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.
MED14 is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 14 (MED14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 14 (MED14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 14 (MED14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 14 (MED14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 14 (MED14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 14 (MED14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 14 (MED14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 14 (MED14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 14 (MED14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 14 (MED14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 14 (MED14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 14 (MED14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 14 (MED14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 14 (MED14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 14 (MED14) ELISA Kit Customized Service Offer
  1. "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method."Genomics 49:237-246(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
  4. "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
  5. ErratumMol. Cell 3:541-541(1999)
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."Mol. Cell 2:213-222(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  9. "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression."J. Biol. Chem. 277:42852-42858(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Role of metazoan mediator proteins in interferon-responsive transcription."Mol. Cell. Biol. 23:620-628(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Selective coactivator interactions in gene activation by SREBP-1a and -1c."Mol. Cell. Biol. 24:8288-8300(2004) [PubMed] [Europe PMC] [Abstract]
  14. "DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs."J. Biol. Chem. 280:8819-8830(2005) [PubMed] [Europe PMC] [Abstract]
  15. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]