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Mediator Complex Subunit 17 (MED17)

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CRSP77; DRIP80; MED17; TRAP80; CRSP6; Activator-recruited cofactor 77 kDa; Cofactor required for Sp1 transcriptional activation 6; Thyroid hormone receptor-associated 80 kDa

Mediator Complex Subunit 17 (MED17)
CCC F091
HGNC 2375
MGI 2182585
PubMed 19114222
RGD 1311120
UniProt Q9NVC6
Wiki MED17
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.
MED17 is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.The extent of this transcript is supported by transcript alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 17 (MED17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 17 (MED17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 17 (MED17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 17 (MED17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 17 (MED17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 17 (MED17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 17 (MED17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 17 (MED17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 17 (MED17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 17 (MED17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 17 (MED17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 17 (MED17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 17 (MED17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 17 (MED17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 17 (MED17) ELISA Kit Customized Service Offer
  1. "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."Mol. Cell 3:361-370(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."J. Biol. Chem. 278:15123-15127(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Role of metazoan mediator proteins in interferon-responsive transcription."Mol. Cell. Biol. 23:620-628(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  11. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex."Am. J. Hum. Genet. 87:667-670(2010) [PubMed] [Europe PMC] [Abstract]