≡

Mediator Complex Subunit 25 (MED25)

[Edit]

P78; ACID1; ARC92; PTOV2; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; Mediator of RNA polymerase II transcription subunit 25

Mediator Complex Subunit 25 (MED25)
CCC F085
HGNC 28845
MGI 1922863
PubMed 17641689
RGD 1305137
UniProt Q71SY5
Wiki MED25
MED25 encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.
The deduced 645-amino acid protein contains a 150-amino acid region similar to a duplicated sequence in PTOV1, but PTOV1 and PTOV2 are dissimilar at their N and C termini. The N-terminal region of PTOV2 has proline- and glutamine-rich stretches, and the C terminus contains a synapsin-related sequence rich in glycine and proline.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 25 (MED25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 25 (MED25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 25 (MED25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 25 (MED25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 25 (MED25) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 25 (MED25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 25 (MED25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 25 (MED25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 25 (MED25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 25 (MED25) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 25 (MED25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 25 (MED25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 25 (MED25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 25 (MED25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 25 (MED25) ELISA Kit Customized Service Offer
  1. "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein."Biochem. Biophys. Res. Commun. 296:281-287(2002) [PubMed] [Europe PMC] [Abstract]
  2. "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells."EMBO J. 22:6494-6504(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator."Proc. Natl. Acad. Sci. U.S.A. 101:2339-2344(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  9. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  10. "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation."EMBO J. 26:3545-3557(2007) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "NMR structure of the human Mediator MED25 ACID domain."J. Struct. Biol. 174:245-251(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models." Neurogenetics 10:275-287(2009) [PubMed] [Europe PMC] [Abstract]
  14. Erratum Neurogenetics 10:375-376(2009)