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Replication Factor C2 (RFC2)

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A1; RFC40; Activator 1; Activator 1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit

Replication Factor C2 (RFC2)
CCC F080
HGNC 9970
MGI 1341868
PubMed 18245774
RGD 621198
UniProt P35250
Wiki RFC2
Studies with the complete 5-subunit holoenzyme indicated that the large subunit binds to DNA and the 40-kD subunit binds ATP. The other subunits may play discrete roles in the elongation process catalyzed by polymerase.
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. Replication Factor C2 isthe 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF080Hu01 Recombinant Replication Factor C2 (RFC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Replication Factor C2 (RFC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C2 (RFC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C2 (RFC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C2 (RFC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF080Mu01 Recombinant Replication Factor C2 (RFC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Replication Factor C2 (RFC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C2 (RFC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C2 (RFC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C2 (RFC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Factor C2 (RFC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Factor C2 (RFC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C2 (RFC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C2 (RFC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C2 (RFC2) ELISA Kit Customized Service Offer
  1. "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells."Proc. Natl. Acad. Sci. U.S.A. 89:2516-2520(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23."Mamm. Genome 11:890-898(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival."Cell Cycle 4:323-329(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]