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Replication Factor C4 (RFC4)

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RFC37; Activator 1 37 kDa subunit; Activator 1 subunit 4; Replication factor C 37 kDa subunit

Replication Factor C4 (RFC4)
CCC F078
HGNC 9972
MGI 2146571
PubMed 12192049
RGD 1310142
UniProt P35249
Wiki RFC4
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD.
RFC4 encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. This subunit may be involved in the elongation of the multiprimed DNA template.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF078Hu01 Recombinant Replication Factor C4 (RFC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Replication Factor C4 (RFC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C4 (RFC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C4 (RFC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C4 (RFC4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF078Mu01 Recombinant Replication Factor C4 (RFC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF078Mu01 Polyclonal Antibody to Replication Factor C4 (RFC4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Replication Factor C4 (RFC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C4 (RFC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Factor C4 (RFC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Factor C4 (RFC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C4 (RFC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C4 (RFC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C4 (RFC4) ELISA Kit Customized Service Offer
  1. "Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells."Proc. Natl. Acad. Sci. U.S.A. 89:5211-5215(1992) [PubMed] [Europe PMC] [Abstract]
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  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]