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Eukaryotic Translation Initiation Factor 3M (EIF3M)

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PCID1; HFLB5; GA17; eIF3m; hfl-B5; PCI Domain Containing 1; Herpesvirus Entry Mediator; Fetal lung protein B5; PCI domain-containing protein 1

Eukaryotic Translation Initiation Factor 3M (EIF3M)
CCC E997
HGNC 24460
MGI 1351744
PubMed 19483676
RGD 1565840
UniProt Q7L2H7
Wiki EIF3M
HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV) The predicted 374-amino acid type II membrane protein contains 2 N-glycosylation sites and a C-terminal heptad repeat that forms a coiled-coil structure. HFLB5 lacks a signal peptide. Microscopic, immunoprecipitation, Western blot, and FACS analyses demonstrated that the HFLB5 C terminus is exposed extracellularly on the cell surface. Northern blot and RT-PCR analyses of human tissues and cell lines revealed broad expression of a 1.3-kb HFLB5 transcript. Entry of HSV into HFLB5-expressing porcine and human cells could be blocked by a 30-mer peptide identical to the HFLB5 C-terminal coiled-coil region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE997Hu01 Recombinant Eukaryotic Translation Initiation Factor 3M (EIF3M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3M (EIF3M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3M (EIF3M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAR-2008) to UniProtKB
  6. "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells."Brain Res. 1170:129-139(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP."Genes Dev. 18:3078-3093(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes."BMC Biol. 3:14-14(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The C-terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection."J. Virol. 79:7431-7437(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."RNA 11:470-486(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."J. Biol. Chem. 281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]
  13. "CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo."Mol. Cell. Biol. 27:4526-4540(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."Mol. Cell. Proteomics 6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."Proc. Natl. Acad. Sci. U.S.A. 105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]