≡

Ring Finger Protein 43 (RNF43)

[Edit]

URCC; E3 ubiquitin-protein ligase RNF43

Ring Finger Protein 43 (RNF43)
CCC E962
HGNC 18505
MGI 2442609
PubMed 23847203
RGD 1305204
UniProt Q68DV7
RNF43 is a HAP95 (AKAP8L) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer.The deduced RNF43 protein contains a signal peptide and a RING finger motif. RNF43 expression in 15 of 18 additional colon cancer samples tested. Immunocytochemistry studies localized RNF43 to spotty granules in the cytoplasm, and further studies demonstrated that RNF43 is a secretory protein.
RNF43 contains a transmembrane domain 5-prime of the RING finger motif and 2 C-terminal nuclear localization signals. Indirect immunofluorescence and biochemical fractionation localized RNF43 protein to the endoplasmic reticulum, and showed that RNF43 colocalized with emerin (EMD) to the inner nuclear membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 43 (RNF43) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 43 (RNF43) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 43 (RNF43) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 43 (RNF43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 43 (RNF43) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 43 (RNF43) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 43 (RNF43) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 43 (RNF43) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 43 (RNF43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 43 (RNF43) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 43 (RNF43) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 43 (RNF43) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 43 (RNF43) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 43 (RNF43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 43 (RNF43) ELISA Kit Customized Service Offer
  1. "A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer."Int. J. Oncol. 25:1343-1348(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Ring finger protein 43 as a new target for cancer immunotherapy."Clin. Cancer Res. 10:8577-8586(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95."Exp. Cell Res. 314:1519-1528(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins."Proteomics 8:2907-2910(2008) [PubMed] [Europe PMC] [Abstract]
  8. "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors."Nature 488:665-669(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The structural basis of R-spondin recognition by LGR5 and RNF43."Genes Dev. 27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]