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Chromodomain Helicase DNA Binding Protein 8 (CHD8)

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HELSNF1; DUPLIN; Helicase With SNF2 Domain 1; ATP-dependent helicase CHD8

Chromodomain Helicase DNA Binding Protein 8 (CHD8)
CCC E927
HGNC 20153
MGI 1915022
PubMed 22083958
RGD 620696
UniProt Q9HCK8
Wiki CHD8
By sequencing clones from a size-fractionated fetal brain cDNA library, Nagase et al. (2000) cloned CHD8, which they designated KIAA1564. The deduced protein contains 1,417 amino acids. RT-PCR ELISA detected moderate expression in all adult and fetal tissues and specific brain regions examined.
Ishihara et al. (2006) cloned mouse Chd8. The deduced 2,582-amino acid protein has 2 chromodomains, followed by a central helicase/ATPase domain and 2 C-terminal BRK domains. Northern blot analysis detected ubiquitous Chd8 expression in mouse tissues, with highest levels in heart and testis. Western blot analysis of HeLa cells detected endogenous CHD8 at an apparent molecular mass of 240 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE927Hu01 Recombinant Chromodomain Helicase DNA Binding Protein 8 (CHD8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 8 (CHD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 8 (CHD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 8 (CHD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 8 (CHD8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 8 (CHD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 8 (CHD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 8 (CHD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 8 (CHD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 8 (CHD8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 8 (CHD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 8 (CHD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 8 (CHD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 8 (CHD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 8 (CHD8) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "CTCF-dependent chromatin insulator is linked to epigenetic remodeling."Mol. Cell 23:733-742(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription."Mol. Cell. Biol. 27:8729-8738(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Novel deletions of 14q11.2 associated with developmental delay, cognitive impairment and similar minor anomalies in three children."J. Med. Genet. 44:556-561(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes."Mol. Cell. Biol. 28:3894-3904(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome."Hum. Mol. Genet. 19:2858-2866(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the first BRK domain from human chromodomain-helicase-DNA-binding protein 8."Submitted (OCT-2006) to the PDB data bank
  22. "Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders." Science 338:1619-1622(2012) [PubMed] [Europe PMC] [Abstract]