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Methyl CpG Binding Domain Protein 1 (MBD1)

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CXXC3; PCM1; RFT; CXXC-type zinc finger protein 3; Methyl-CpG-binding protein MBD1; Protein containing methyl-CpG-binding domain 1

Methyl CpG Binding Domain Protein 1 (MBD1)
CCC E921
HGNC 6916
MGI 1333811
PubMed 20452318
RGD 1305980
UniProt Q9UIS9
Wiki MBD1
MBD1binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9 is a repressive modification. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich domains, and some differences in the COOH terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE921Hu01 Recombinant Methyl CpG Binding Domain Protein 1 (MBD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Methyl CpG Binding Domain Protein 1 (MBD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyl CpG Binding Domain Protein 1 (MBD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyl CpG Binding Domain Protein 1 (MBD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyl CpG Binding Domain Protein 1 (MBD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methyl CpG Binding Domain Protein 1 (MBD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methyl CpG Binding Domain Protein 1 (MBD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyl CpG Binding Domain Protein 1 (MBD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyl CpG Binding Domain Protein 1 (MBD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyl CpG Binding Domain Protein 1 (MBD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methyl CpG Binding Domain Protein 1 (MBD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methyl CpG Binding Domain Protein 1 (MBD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyl CpG Binding Domain Protein 1 (MBD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyl CpG Binding Domain Protein 1 (MBD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyl CpG Binding Domain Protein 1 (MBD1) ELISA Kit Customized Service Offer
  1. "A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins."Nat. Genet. 16:256-259(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes."Mamm. Genome 10:906-912(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms."Mol. Cell. Biol. 19:6415-6426(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1."Eur. J. Biochem. 271:628-636(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a family of mammalian methyl-CpG binding proteins."Mol. Cell. Biol. 18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Active repression of methylated genes by the chromosomal protein MBD1."Mol. Cell. Biol. 20:1394-1406(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression."J. Biol. Chem. 278:24132-24138(2003) [PubMed] [Europe PMC] [Abstract]
  11. "MCAF mediates MBD1-dependent transcriptional repression."Mol. Cell. Biol. 23:2834-2843(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1."Mol. Cell. Biol. 23:3226-3236(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression."J. Biol. Chem. 279:6783-6793(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly."Mol. Cell 15:595-605(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins."J. Biol. Chem. 280:13928-13935(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins."EMBO J. 25:5317-5328(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation."J. Biol. Chem. 281:23180-23190(2006) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Human BAHD1 promotes heterochromatic gene silencing."Proc. Natl. Acad. Sci. U.S.A. 106:13826-13831(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1."EMBO J. 18:6653-6661(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin."Proc. Natl. Acad. Sci. U.S.A. 100:12859-12864(2003) [PubMed] [Europe PMC] [Abstract]