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Sirtuin 4 (SIRT4)

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SIR2L4; Silent Mating Type Information Regulation 2 Homolog 4; SIR2-like protein 4; NAD-dependent protein deacetylase sirtuin-4

Sirtuin 4 (SIRT4)
CCC E914
HGNC 14932
MGI 1922637
PubMed 20685656
RGD 1310413
UniProt Q9Y6E7
Wiki SIRT4
SIRT4 encodes a member of the sirtuin family of proteins which are homologs of the Sir2 gene in budding yeast. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity, thereby downregulating insulin secretion in response to amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE914Hu01 Recombinant Sirtuin 4 (SIRT4) Positive Control; Immunogen; SDS-PAGE; WB.
APE914Hu01 Active Sirtuin 4 (SIRT4) Cell culture; Activity Assays.
Antibodies PAE914Hu01 Polyclonal Antibody to Sirtuin 4 (SIRT4) WB; IHC; ICC; IP.
MAE914Hu21 Monoclonal Antibody to Sirtuin 4 (SIRT4) WB; IHC; ICC; IP.
Assay Kits SEE914Hu ELISA Kit for Sirtuin 4 (SIRT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE914Mu01 Recombinant Sirtuin 4 (SIRT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE914Mu01 Polyclonal Antibody to Sirtuin 4 (SIRT4) WB; IHC; ICC; IP.
LAE914Mu71 Biotin-Linked Polyclonal Antibody to Sirtuin 4 (SIRT4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Sirtuin 4 (SIRT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sirtuin 4 (SIRT4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE914Ra01 Recombinant Sirtuin 4 (SIRT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE914Ra01 Polyclonal Antibody to Sirtuin 4 (SIRT4) WB; IHC; ICC; IP.
LAE914Ra71 Biotin-Linked Polyclonal Antibody to Sirtuin 4 (SIRT4) WB; IHC; ICC.
Assay Kits SEE914Ra ELISA Kit for Sirtuin 4 (SIRT4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity."Biochem. Biophys. Res. Commun. 260:273-279(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells."Cell 126:941-954(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase."J. Biol. Chem. 282:33583-33592(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
  7. "SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism." Cancer Cell 23:450-463(2013) [PubMed] [Europe PMC] [Abstract]
  8. "The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4."Cell 153:840-854(2013) [PubMed] [Europe PMC] [Abstract]