≡

Histone Deacetylase 8 (HDAC8)

[Edit]

RPD3; HDACL1; Histone Deacetylase-Like 1

Histone Deacetylase 8 (HDAC8)
CCC E908
HGNC 13315
MGI 1917565
PubMed 22885700
RGD 1562895
UniProt Q9BY41
Wiki HDAC8
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.HDAC8 shares 54% sequence similarity with HDAC1 and HDAC2 and 39% similarity with HDAC3, making it a class I HDAC. Northern blot analysis detected HDAC8 transcripts of approximately 2.0 and 2.4 kb in all normal tissues tested, with strongest expression in brain, unlike other class I HDACs, and in cancer cell lines. Immunofluorescence analysis indicated a nuclear localization with possible exclusion from the nucleolus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE908Hu01 Recombinant Histone Deacetylase 8 (HDAC8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE908Hu01 Polyclonal Antibody to Histone Deacetylase 8 (HDAC8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histone Deacetylase 8 (HDAC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 8 (HDAC8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Deacetylase 8 (HDAC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 8 (HDAC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 8 (HDAC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 8 (HDAC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 8 (HDAC8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Deacetylase 8 (HDAC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 8 (HDAC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 8 (HDAC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 8 (HDAC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 8 (HDAC8) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor."J. Biol. Chem. 275:15254-15264(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a novel human histone deacetylase, HDAC8."Biochem. J. 350:199-205(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of human histone deacetylase 8."FEBS Lett. 478:77-83(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia."Genomics 64:221-229(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Normalization and subtraction: two approaches to facilitate gene discovery."Genome Res. 6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain."Mol. Cell. Biol. 23:607-619(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A."Mol. Cell. Biol. 24:765-773(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility."FASEB J. 19:966-968(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus."Am. J. Surg. Pathol. 30:319-327(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation."Mol. Cell. Biol. 26:5259-5269(2006) [PubMed] [Europe PMC] [Abstract]
  15. "X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face."J. Med. Genet. 49:539-543(2012) [PubMed] [Europe PMC] [Abstract]
  16. "HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle." Nature 489:313-317(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases." Structure 12:1325-1334(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex."EMBO Rep. 8:879-884(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors."Biochemistry 47:13554-13563(2008) [PubMed] [Europe PMC] [Abstract]