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Histone Deacetylase 6 (HDAC6)

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HD6; JM21

Histone Deacetylase 6 (HDAC6)
CCC E906
HGNC 14064
MGI 1333752
PubMed 22457490
RGD 619981
UniProt Q9UBN7
Wiki HDAC6

HDAC6 belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.Sequence analysis predicted that the 1,216-amino acid HDAC6 protein consists of an apparent internal dimer containing 2 highly homologous catalytic domains, the first beginning at residue 215 and the second at residue 610. Northern blot analysis detected expression of a 5.0-kb HDAC6 transcript that was highest in heart, liver, kidney, and pancreas. Functional analysis confirmed that HDAC6 possesses deacetylation activity against all 4 core histones and that the 2 catalytic domains function independently.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE906Hu01 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE906Hu02 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE906Hu03 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
APE906Hu01 Active Histone Deacetylase 6 (HDAC6) Cell culture; Activity Assays.
RPE906Hu04 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE906Hu01 Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC; IP.
PAE906Hu02 Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC; IP.
LAE906Hu71 Biotin-Linked Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC.
Assay Kits SEE906Hu ELISA Kit for Histone Deacetylase 6 (HDAC6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE906Mu01 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE906Mu02 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
APE906Mu01 Active Histone Deacetylase 6 (HDAC6) Cell culture; Activity Assays.
Antibodies PAE906Mu01 Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC; IP.
PAE906Mu02 Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC; IP.
Assay Kits SEE906Mu ELISA Kit for Histone Deacetylase 6 (HDAC6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE906Ra01 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE906Ra01 Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histone Deacetylase 6 (HDAC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 6 (HDAC6) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE906Po01 Recombinant Histone Deacetylase 6 (HDAC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE906Po01 Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histone Deacetylase 6 (HDAC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 6 (HDAC6) ELISA Kit Customized Service Offer
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  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family."J. Biol. Chem. 277:25748-25755(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."EMBO J. 21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes."Proc. Natl. Acad. Sci. U.S.A. 99:13425-13430(2002) [PubMed] [Europe PMC] [Abstract]
  9. "HDAC6 is a microtubule-associated deacetylase."Nature 417:455-458(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase."Mol. Cell 11:437-444(2003) [PubMed] [Europe PMC] [Abstract]
  11. "HEF1-dependent Aurora A activation induces disassembly of the primary cilium."Cell 129:1351-1363(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."J. Biol. Chem. 282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6."J. Cell Biol. 178:1025-1038(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin."Mol. Cell. Biochem. 303:221-230(2007) [PubMed] [Europe PMC] [Abstract]
  15. "A BBSome subunit links ciliogenesis, microtubule stability and acetylation."Dev. Cell 15:854-865(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition."J. Cell Sci. 121:4079-4088(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation."Biochem. Biophys. Res. Commun. 392:608-613(2010) [PubMed] [Europe PMC] [Abstract]
  18. "CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."EMBO J. 29:131-144(2010) [PubMed] [Europe PMC] [Abstract]
  19. "A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia."Hum. Mol. Genet. 19:2015-2027(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."Cancer Res. 74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation."FASEB J. 28:2955-2969(2014) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of human HDAC6 zinc finger domain."Submitted (FEB-2008) to the PDB data bank
  25. "Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG."Submitted (APR-2009) to the PDB data bank