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Anterior Pharynx Defective 1B (APH1B)

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PSFL; APH-1B; Gamma-secretase subunit APH-1B; Presenilin-stabilization factor-like

Anterior Pharynx Defective 1B (APH1B)
CCC E896
HGNC 24080
MGI 3522097
PubMed 18626010
RGD 1562468
UniProt Q8WW43
APH1 is a multipass transmembrane protein that interacts with presenilin and nicastrin (APH2) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein and Notch.
APH1B encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anterior Pharynx Defective 1B (APH1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anterior Pharynx Defective 1B (APH1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anterior Pharynx Defective 1B (APH1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anterior Pharynx Defective 1B (APH1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anterior Pharynx Defective 1B (APH1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anterior Pharynx Defective 1B (APH1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anterior Pharynx Defective 1B (APH1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anterior Pharynx Defective 1B (APH1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anterior Pharynx Defective 1B (APH1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anterior Pharynx Defective 1B (APH1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anterior Pharynx Defective 1B (APH1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anterior Pharynx Defective 1B (APH1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anterior Pharynx Defective 1B (APH1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anterior Pharynx Defective 1B (APH1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anterior Pharynx Defective 1B (APH1B) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a novel human APH-1b splice variant lacking exon 4."Biochem. Biophys. Res. Commun. 330:1068-1072(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch."J. Biol. Chem. 277:45013-45019(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2."Proc. Natl. Acad. Sci. U.S.A. 100:6382-6387(2003) [PubMed] [Europe PMC] [Abstract]