A Kinase Anchor Protein 14 (AKAP14)

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family.

AKAP14 anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.HBE cells detected upregulation of a 0.8-kb AKAP28 transcript as cells differentiated and began to display a mucociliary phenotype. expression of AKAP28 in trachea and testis, the only tissues examined that contain axoneme-based organelles.