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Sorting Nexin 1 (SNX1)

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SNX1A; Vps5

Sorting Nexin 1 (SNX1)
CCC E886
HGNC 11172
MGI 1928395
PubMed 17101778
RGD 68935
UniProt Q13596
Wiki SNX1
SNX1 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.
The major difference between SNX1 and SNX1A is a deletion of 195 nucleotides that results in an in-frame deletion of 65 amino acids; thus, SNX1A cDNA is predicted to encode a 457-amino acid hydrophilic protein. By PCR, the authors confirmed the presence of both SNX1 and SNX1A mRNAs in multiple tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE886Hu01 Recombinant Sorting Nexin 1 (SNX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Sorting Nexin 1 (SNX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 1 (SNX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 1 (SNX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 1 (SNX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 1 (SNX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 1 (SNX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 1 (SNX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 1 (SNX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 1 (SNX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 1 (SNX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 1 (SNX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 1 (SNX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 1 (SNX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 1 (SNX1) ELISA Kit Customized Service Offer
  1. "Enhanced degradation of EGF receptors by a sorting nexin, SNX1."Science 272:1008-1010(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a family of sorting nexin molecules and characterization of their association with receptors."Mol. Cell. Biol. 18:7278-7287(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation."J. Biol. Chem. 277:48730-48736(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Endosomal localization and function of sorting nexin 1."Proc. Natl. Acad. Sci. U.S.A. 99:6767-6772(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides."Curr. Biol. 14:1791-1800(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins."Mol. Biol. Cell 17:1228-1238(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network."J. Cell Sci. 120:2010-2021(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors."Mol. Cell. Biol. 27:1112-1124(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors."Traffic 9:380-393(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport."Cell Res. 19:1334-1349(2009) [PubMed] [Europe PMC] [Abstract]
  17. "The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."Dev. Cell 17:110-122(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Amphipathic motifs in BAR domains are essential for membrane curvature sensing."EMBO J. 28:3303-3314(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes."Traffic 10:1868-1880(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking."Biochem. Biophys. Res. Commun. 403:167-171(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling."Traffic 11:1347-1362(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent."Traffic 11:508-519(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice."J. Biol. Chem. 288:152-163(2013) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Determinants of the endosomal localization of sorting nexin 1."Mol. Biol. Cell 16:2049-2057(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules."EMBO J. 31:4466-4480(2012) [PubMed] [Europe PMC] [Abstract]