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Sorting Nexin 3 (SNX3)

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SDP3; SNX3A; Grd19

Sorting Nexin 3 (SNX3)
CCC E873
HGNC 11174
MGI 1860188
PubMed 21725319
UniProt O60493
Wiki SNX3
Sorting nexin-3 is member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.
The SNX3 cDNA encodes a deduced 162-amino acid protein. Northern blot analysis detected an approximately 1.9-kb SNX3 transcript in all tissues tested, with highest expression in peripheral leukocytes, spleen, heart, and skeletal muscle, and low expression in kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 3 (SNX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 3 (SNX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 3 (SNX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 3 (SNX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 3 (SNX3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 3 (SNX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 3 (SNX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 3 (SNX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 3 (SNX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 3 (SNX3) ELISA Kit Customized Service Offer
  1. "Identification of a family of sorting nexin molecules and characterization of their association with receptors."Mol. Cell. Biol. 18:7278-7287(1998) [PubMed] [Europe PMC] [Abstract]
  2. "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P."Nat. Cell Biol. 3:658-666(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype."J. Med. Genet. 39:893-899(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2."Acta Biochim. Biophys. Sin. 39:540-546(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies."PLoS Biol. 6:E214-E214(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole."Cell. Microbiol. 12:1352-1367(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."Nat. Cell Biol. 13:914-923(2011) [PubMed] [Europe PMC] [Abstract]
  17. "SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells."Immunology 139:30-47(2013) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy."Mol. Cell. Proteomics 13:2233-2245(2014) [PubMed] [Europe PMC] [Abstract]
  20. "A mechanism for retromer endosomal coat complex assembly with cargo."Proc. Natl. Acad. Sci. U.S.A. 111:267-272(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of the PX domain of human sorting nexin 3."Submitted (MAR-2013) to the PDB data bank