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Diacylglycerol Kinase Theta (DGKq)

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DAGK; DAGK4; DAGK7; Diglyceride kinase theta

Diacylglycerol Kinase Theta (DGKq)
CCC E853
HGNC 2856
MGI 102918
PubMed 22438815
UniProt P52824
Wiki DGKQ
Diacylglycerol kinase theta is an enzyme contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
The predicted 882-amino acid human protein is 90% identical to rat DGK-theta. Sequence analysis revealed that DGK-theta contains a pleckstrin homology domain and the conserved DGK putative catalytic domain. However, unlike other DGK isotypes, DGK-theta contains 3 rather than 2 cysteine-rich zinc-binding domains, an N-terminal proline- and glycine-rich region, and a RAS-associating domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE853Hu01 Recombinant Diacylglycerol Kinase Theta (DGKq) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Diacylglycerol Kinase Theta (DGKq) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diacylglycerol Kinase Theta (DGKq) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diacylglycerol Kinase Theta (DGKq) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diacylglycerol Kinase Theta (DGKq) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diacylglycerol Kinase Theta (DGKq) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diacylglycerol Kinase Theta (DGKq) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diacylglycerol Kinase Theta (DGKq) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diacylglycerol Kinase Theta (DGKq) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diacylglycerol Kinase Theta (DGKq) ELISA Kit Customized Service Offer
  1. "Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene."Genomics 26:599-601(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA."J. Biol. Chem. 274:6820-6822(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus."Exp. Cell Res. 287:143-154(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Structure-activity relationship of diacylglycerol kinase theta."Biochim. Biophys. Acta 1636:169-174(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C."J. Biol. Chem. 280:9870-9878(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17."Mol. Cell. Biol. 27:6669-6685(2007) [PubMed] [Europe PMC] [Abstract]