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Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)

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SCAR2; WAVE2; Verprolin homology domain-containing protein 2

Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)
CCC E773
HGNC 12733
MGI 1098641
PubMed 23435376
RGD 1307299
UniProt Q9Y6W5
Wiki WASF2
Wiskott-Aldrich syndrome protein family member 2 is a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members.
The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE773Hu01 Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE773Hu02 Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE773Hu21 Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) WB; IHC; ICC; IP.
PAE773Hu01 Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) WB; IHC; ICC; IP.
Assay Kits SEE773Hu ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE773Mu01 Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE773Mu02 Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE773Mu01 Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) WB; IHC; ICC; IP.
PAE773Mu02 Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) WB; IHC; ICC; IP.
Assay Kits SEE773Mu ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) ELISA Kit Customized Service Offer
  1. "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex."Biochem. Biophys. Res. Commun. 260:296-302(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling."Nature 408:732-735(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and architecture of the ubiquitous Wave complex."Proc. Natl. Acad. Sci. U.S.A. 101:4379-4383(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structure and control of the actin regulatory WAVE complex."Nature 468:533-538(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells."Cell Host Microbe 16:201-214(2014) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly."Proc. Natl. Acad. Sci. U.S.A. 102:16644-16649(2005) [PubMed] [Europe PMC] [Abstract]